The effect of donor's substance use disorders on acute heart transplantation rejection
AHMED ALNAJAR1, Eugene Blackstone2, Raymond Balise1, Layla Amal Bouzoubaa1, Tawseef Dar1, Ana Palacio1, Matthias Loebe1, Abbas Rana3, J Sunil Rao1.
1University of Miami, Miami, FL, USA, 2Cleveland Clinic, Cleveland, OH, USA, 3Baylor College of Medicine, Houston, TX, USA.
Substance use disorders represent a major public health crisis that may affect the quality of the donor pool for heart transplantation. Since cocaine and its metabolites have been shown to play a role in the immunomodulatory activity, it should be studied among the immunologic risk factors for acute rejection in heart transplantation.
METHODS: We studied a cohort of 139,875 kidney transplant recipients from the Organ Procurement and Transplantation Network (OPTN) database between 2010 and 2020. We utilized univariable and multivariable logistic regression analyses on the data and identified independent risk factors for treated acute rejection at 1 year.
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